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Second, the PSA test cannot tell which cancers are likely to be indolent and which are aggressive. That means routine screening will detect many tumors that would never cause harm, a problem called over diagnosis. Even worse, since a diagnosis of prostate cancer in the United States usually leads to treatment, PSA testing leads to over treatment. Despite advances in therapy, significant side effects are common, with erectile dysfunction heading the list and urinary incontinence in second place. So while PSA testing surely saves some lives, it also produces substantial distress in other men who never needed any treatment (http://guardamarturisme.com).